Hesham M Korashy Selected Research

Hepatocellular Carcinoma (Hepatoma)

10/2019	Phloretin attenuates STAT-3 activity and overcomes sorafenib resistance targeting SHP-1-mediated inhibition of STAT3 and Akt/VEGFR2 pathway in hepatocellular carcinoma.
3/2016	Ketoconazole Stereoisomers Differentially Induce Cytochrome P450 1A1 Between Human Hepatoma HepG2 and Mouse Hepatoma Hepa1c1c7 Cells.
4/2014	Thymoquinone suppression of the human hepatocellular carcinoma cell growth involves inhibition of IL-8 expression, elevated levels of TRAIL receptors, oxidative stress and apoptosis.
1/2012	Transcriptional and posttranslational mechanisms modulating the expression of the cytochrome P450 1A1 gene by lead in HepG2 cells: a role of heme oxygenase.
1/2012	Camel milk modulates the expression of aryl hydrocarbon receptor-regulated genes, Cyp1a1, Nqo1, and Gsta1, in murine hepatoma Hepa 1c1c7 cells.
9/2011	The p38 MAPK inhibitor SB203580 induces cytochrome P450 1A1 gene expression in murine and human hepatoma cell lines through ligand-dependent aryl hydrocarbon receptor activation.
1/2011	Camel urine inhibits the cytochrome P450 1a1 gene expression through an AhR-dependent mechanism in Hepa 1c1c7 cell line.
2/2008	Modulation of TCDD-mediated induction of cytochrome P450 1A1 by mercury, lead, and copper in human HepG2 cell line.
5/2007	Induction of cytochrome P450 1A1 by ketoconazole and itraconazole but not fluconazole in murine and human hepatoma cell lines.
9/2006	The role of aryl hydrocarbon receptor and the reactive oxygen species in the modulation of glutathione transferase by heavy metals in murine hepatoma cell lines.

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Hesham M Korashy Research Topics

Disease

24	Neoplasms (Cancer) 03/2024 - 12/2007
12	Hepatocellular Carcinoma (Hepatoma) 10/2019 - 09/2004
9	Inflammation (Inflammations) 03/2024 - 02/2015
9	Breast Neoplasms (Breast Cancer) 01/2023 - 05/2013
8	Cardiotoxicity 09/2023 - 01/2012
6	Carcinogenesis 03/2024 - 04/2015
5	Cardiovascular Diseases (Cardiovascular Disease) 03/2024 - 01/2006
4	Obesity 11/2022 - 04/2019
4	Pneumonia (Pneumonitis) 09/2022 - 02/2015
4	Heart Failure 01/2021 - 04/2013
3	Ovarian Neoplasms (Ovarian Cancer) 02/2024 - 01/2022
3	Insulin Resistance 11/2022 - 03/2015
3	Hyperglycemia 03/2022 - 07/2011
3	Hypertension (High Blood Pressure) 01/2021 - 01/2014
3	Hypertrophy 01/2020 - 04/2013
3	Cardiomegaly (Heart Hypertrophy) 03/2014 - 01/2012
2	Neoplasm Metastasis (Metastasis) 01/2024 - 06/2022
2	Diabetes Mellitus 11/2022 - 03/2022
2	BCR-ABL Positive Chronic Myelogenous Leukemia (Chronic Myelogenous Leukemia) 06/2022 - 01/2014
2	Vascular Remodeling 03/2022 - 01/2020
2	Heart Diseases (Heart Disease) 01/2021 - 01/2012
2	Lung Neoplasms (Lung Cancer) 03/2020 - 11/2018
2	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 01/2020 - 01/2014
2	Acute Lung Injury 05/2016 - 02/2015
2	Diabetic Nephropathies (Diabetic Nephropathy) 03/2015 - 07/2011
1	Sepsis (Septicemia) 01/2023
1	Acute Kidney Injury (Acute Renal Failure) 01/2023
1	Colonic Neoplasms (Colon Cancer) 12/2022
1	Uterine Cervical Neoplasms (Cancer of the Cervix) 11/2022
1	Myeloid Leukemia (Leukemia, Myelocytic) 06/2022

Drug/Important Bio-Agent (IBA)

25	Aryl Hydrocarbon Receptors (Aryl Hydrocarbon Receptor)IBA 03/2024 - 09/2004
16	Proteins (Proteins, Gene)FDA Link 03/2024 - 05/2007
15	Cytochrome P-450 CYP1A1 (CYP1A1)IBA 01/2023 - 09/2004
12	Cytochrome P-450 Enzyme System (Cytochrome P450)IBA 01/2017 - 04/2004
11	Messenger RNA (mRNA)IBA 01/2020 - 05/2007
8	Tyrosine Kinase InhibitorsIBA 09/2023 - 05/2013
8	EnzymesIBA 11/2016 - 04/2004
6	LigandsIBA 03/2024 - 09/2004
5	Environmental Pollutants (Pollutants, Environmental)IBA 03/2024 - 08/2021
5	Polychlorinated Dibenzodioxins (TCDD)IBA 02/2024 - 09/2004
5	Oxidoreductases (Dehydrogenase)IBA 01/2023 - 04/2004
5	Metformin (Glucophage)FDA LinkGeneric 02/2022 - 07/2011
5	CytochromesIBA 01/2022 - 04/2013
5	Sunitinib (Sutent)FDA Link 01/2017 - 05/2013
4	NAD (NADH)IBA 01/2023 - 09/2004
4	quinone (benzoquinone)IBA 01/2023 - 09/2004
4	CateninsIBA 06/2022 - 01/2017
4	Heavy MetalsIBA 02/2017 - 09/2004
4	AntioxidantsIBA 11/2016 - 02/2011
3	LipopolysaccharidesIBA 01/2023 - 01/2015
3	Transcription Factors (Transcription Factor)IBA 11/2022 - 04/2014
3	Polycyclic Aromatic Hydrocarbons (Polynuclear Aromatic Hydrocarbons)IBA 11/2022 - 01/2006
3	LeptinIBA 03/2022 - 01/2020
3	AdiponectinIBA 03/2022 - 01/2020
3	Gefitinib (Iressa)FDA Link 01/2020 - 01/2014
3	CytokinesIBA 05/2016 - 04/2015
3	Ketoconazole (Nizoral)FDA LinkGeneric 03/2016 - 05/2007
3	CarrageenanIBA 11/2015 - 02/2015
3	Reactive Oxygen Species (Oxygen Radicals)IBA 01/2013 - 09/2006
3	Glutathione Transferase (Glutathione S-Transferase)IBA 01/2012 - 09/2004
2	Biomarkers (Surrogate Marker)IBA 02/2024 - 01/2020
2	Mitogen-Activated Protein KinasesIBA 09/2023 - 01/2022
2	DioxinsIBA 11/2022 - 01/2013
2	lead nitrateIBA 09/2022 - 09/2022
2	AdipokinesIBA 03/2022 - 01/2021
2	anthraceneIBA 12/2021 - 04/2015
2	CreatinineIBA 08/2019 - 03/2015
2	Urea (Carbamide)FDA LinkGeneric 08/2019 - 03/2015
2	SmokeIBA 02/2019 - 01/2012
2	CatalaseIBA 11/2016 - 03/2015
2	Caspase 3 (Caspase-3)IBA 11/2016 - 06/2016
2	CarcinogensIBA 04/2015 - 12/2007
2	ResveratrolIBA 03/2014 - 04/2013
2	SB 203580IBA 03/2014 - 09/2011
2	Creatine Kinase (Creatine Phosphokinase)IBA 04/2013 - 04/2013
2	CopperIBA 02/2008 - 09/2004
2	MercuryIBA 02/2008 - 09/2004
2	AzolesIBA 12/2007 - 05/2007
2	Itraconazole (Sporanox)FDA LinkGeneric 12/2007 - 05/2007
2	beta-NaphthoflavoneIBA 11/2004 - 09/2004
2	Benzo(a)pyreneIBA 11/2004 - 09/2004
2	MethylcholanthreneIBA 11/2004 - 09/2004
1	apabetaloneIBA 03/2024
1	ProteomeIBA 02/2024
1	Protein Isoforms (Isoforms)IBA 09/2023
1	90-kDa Ribosomal Protein S6 Kinases (Ribosomal Protein S6 Kinases, 90 kDa)IBA 09/2023
1	6-formylindolo(3,2-b)carbazoleIBA 01/2023
1	Phosphates (Orthophosphate)IBA 01/2023
1	Phenobarbital (Luminal)FDA Link 01/2023
1	EndotoxinsIBA 01/2023
1	Heme Oxygenase-1IBA 01/2023
1	CurcuminIBA 12/2022
1	Glucose (Dextrose)FDA LinkGeneric 11/2022
1	G-Protein-Coupled Receptors (Receptors, G Protein Coupled)IBA 11/2022
1	NF-kappa B (NF-kB)IBA 09/2022
1	XenobioticsIBA 06/2022
1	polyethylene glycol-poly(lactide-co-glycolide)IBA 06/2022
1	Polylactic Acid-Polyglycolic Acid CopolymerIBA 06/2022

Therapy/Procedure

8	Therapeutics 03/2024 - 01/2014
1	Drug Therapy (Chemotherapy) 11/2022